As we already reported, Andrea Bowen (Julie) will no longer be living on Wisteria Lane come next Fall.
Who else is definitely gone? A lot of the younger people, including Joy Lauren (Danielle), Lyndsy Fonseca (Dylan), and Brent and Shane Kinsman (Lynette's devil twins).
None of these absences will be all that impactive on the series (in my opinion), as they were never major roles anyway. However, a bigger shock would be if James Denton (Mike Delfino) were not to return, which is the current word on the street (or at least that his departure is a distinct possibility).
It kind of makes sense if Mike is gone, since we know that Susan is no longer with him 5 years in the future. However, it will certainly still seem like a big change for the show since Mike has been there since the beginning. And, if Mike truly is gone, the somewhat pressing question still remains, what exactly did happen to him (and Susan)?
Source: Buddy TV