You've seen SideReel's first 5 shows that jumped the shark, and now it's time for Part 2:
Prison Break - You could see how a show entitled Prison Break might get itself into trouble in terms of keeping things fresh. Frankly, after the break-out in the first season, the show never lived up to that same quality again. The Season 2 Manhunt seemed to lack focus...and by Season 3 (back in prison, because breaking out once wasn't enough)...I was finished.
Smallville - I can't pinpoint this show's jumping the shark to a specific season or episode (you true fans can help me out), but I recall a time when I was watching the program and I thought to myself..."This guy used to be so hot". This is not to say that Tom Welling still isn't a perfectly attractive and appealing lead, but face it...he's on the verge of 32. He is no longer a young Clark Kent and Smallville is no longer a young show. Throw in the departure of some of the show's key players...and you know this one has overstayed its welcome.
Grey's Anatomy - Some of you cited this show in the comments of Part 1...and I couldn't agree more! When did Grey's 'Jump the Shark'? It really went off the deep end when Izzie starting seeing dead people. And talking to them. And having sex with them. But I'm going to be bold and call the "jump moment" even earlier. This might be a mere correlation and not a cause, but this show has been a stank mess ever since the end of the 3rd season when Burke left (which is not to say I still don't watch every minute of it).
Scrubs - I was a Scrubs fanatic from the beginning...so it pains me to say this, but the show has jumped the shark. This last season on ABC especially has done nothing except detract from the show's overall legacy. What really killed it for me was that aired-out-of-order "My Princess" episode on NBC last season. Cute episode. Made no sense continuity-wise. And this season? Sorry, but it's just not that funny anymore. It's a 30 minute drama being sold to us as a comedy, and that makes me sad.
Nip/Tuck - For its first 2 seasons, Nip/Tuck was the most inventive thing on television. Then...there was that whole Eva storyline, and the Carver, and it's only gotten worse from there. There's only so many times that a crazy person can attempt to kill Sean and/or Christian before we call shenanigans on the show. For Nip/Tuck, I will pin the shark jump to the point at which they packed up and moved to LA. Sometimes, a change of scenery can do a show good. I was really optimistic at first when this change occurred, but it quickly sank back to its same degree of absurdity, if not more. Colleen the teddy-bear-making faux-agent from hell? Don't get me started...
Which shows do you think have jumped the shark? Are we missing your selection? Do you disagree with ours? Discuss!