The show takes a bit of time to get up and running in my opinion, but once it does it's a fun ride. The humor is pretty dry in most cases, and sometimes the themes a little to weighty in comparison, but for the most part a well-balanced story. Some of the episodes just make you want to cringe and make even your bones feel a little bit cold, others leave you with that warm happy feeling. The fact that it got canceled made the ending all sorts of rushed and left lots of loose ends, but I guess that gives it more of a sense of reality (seeing as how the real world isn't too tidy either). The main characters are interesting and diverse and mostly are the driving factors of any sort of continuous story line.
One warning: If lots of profanity bothers you, I would stay away...it can be a bit course for the more sensitive ears.