Gilmore Girls - Milo Ventimiglia & Alexis Bledel
Besides the sweet love of this duo's on-screen mother and uncle, the high school romance of Rory Gilmore and Jess Mariano was one of the greatest heartbreaking romances of the WB - but even better? That the addictive on-screen chemistry wasn't just the amazing acting of Alexis and Milo, but also their true attraction shining through! Alexi and Milo dated for 3 1/2 years, from about December 2002 - July 2006, aka during Seasons 3 - 6. So they began dating around the time Rory and Jess were in the beginning of their relationship, and then ended during Rory's Yale days with Logan, and just months before Milo's new hit gig of Heroes premiered.
The O.C. - Adam Brody & Rachel Bilson
Another adorable on-screen couple from a WB fav, Seth and Summer, also took their romance off-camera dating for 3 years from 2003 to December 2006. This would put them at beginning to date in the 1st season of The O.C., perhaps meaning just like her on-screen counter-part, Rachel found herself wooed by the adorable and funny Seth/Adam, but then they grew apart until their 2006 break up about where Seth and Summer were trying to work things out in their college days and the final season of The O.C.
Felicity - Keri Russell & Scott Speedman
The purpose of Felicity was to discover if Felicity and the boy she followed to college, Ben, were meant to be or if Felicity was just a stalker, and surprise! She was a stalker because they were meant to be! It didn't hurt their on-screen chemistry and romantic development that these two began dating near the beginning of Felicity's 4 season run in 1998 and dated throughout almost the entire series. Sadly, though, they didn't find their soul mate in each other like their on-screen counterparts as they broke up in 2001, but when Felicity wrapped up in 2002, Felicity and Ben officially got their happy ending.
House - Jennifer Morrison & Jesse Spencer
On House, it's always about disastrous relationships, and well, it looked like though their on-screen selves were struggling, the real-life Chase and Cameron, aka Jennifer and Jesse, were going to make it to happily ever after... or not. Jennifer and Jesse met in March 2004 at the airport on the way to shoot the first House episode, and they started dating in July 2004. In January 2007, they got engaged in Paris, but then that August, called off the engagement. Ironically, on-screen, there was plenty of Chase-Cameron flirtation, but the characters didn't get together until May 2007 in Season 3, so while their on-screen characters were just getting together, just months later their real-life romance came to an end... for now?
True Blood - Anna Paquin & Stephen Moyer
Oh, the sexy vampire-telepathist romance of True Blood's Sookie and Bill! While some fans of True Blood strongly dislike this coupling, their chemistry on-screen is overwhelming and was one of the most intriguing parts of the 1st season - and apparently the pair agreed in finding that on-screen chemistry overwhelming as it led to their real-life mortal romance! Anna and Stephen began dating right around filming the first episode of the new series, and so far, unlike the star-crossed Sookie and Bill, are still going strong!