As we open, Meredith is apparently acting as the spellmaster for the spelling bee; her voiceover tells us, "'Intimacy' is a four-syllable word for, 'Here are my heart and soul. Please grind them into hamburger.'" Oh, I was mistaken -- she's at home writing the monthly check to the nursing home where her mother is staying.
As the VO continues, Izzie walks into the bathroom where George is taking a shower. We get just a hint of pasty ass through the frosted glass of the shower door. George sees Izzie and freaks out. She grabs a toothbrush, starts to brush her teeth, and walks away. As she leaves, George sticks his head out of the shower and yells, "Is that my toothbrush?" I'm all for roommates walking around in their skivvies, but the fact that the first thought in George's head is that Izzie might be using his toothbrush tells me that Izzie has got some serious boundary issues.