Why was Izzie such a freakin HATER?!?!?

Okay, so I've seen all of season 5, all of season 6 thus far, all of season 1, and now I'm almost finishing my season 2 DVD. One thing I do not understand ---why is Izzie(and kinda Meredith as well) such a hater towards Callie? And that hand washing thing was blown Sooooo outta proportion. I just really don't see what she has done so far to make Izzie hate her that much?

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