As a newbie to the Gossip Girl 'verse (who's seen almost all of the episodes), the characters on The CW hit play what looks to be a game of relationship musical chairs. The four main characters - Blair (Leighton Meester), Serena (Blake Lively), Nate (Chace Crawford), and Chuck (Ed Westwick) - seem to be in the quintessential teen clique the way pop culture typically represents it, that is to say, everyone either dates or sleeps with everyone else. Of course, the faithfulness of this in real life is hard to define, as some groups will fall into this classification and some will not.
For one, Blair had both Nate and Chuck (plus Lord Marcus). Serena had Nate (and in the book is referred as her true love if such exists in Gossip Girl parlance) and Dan (Penn Badgley), of course. Nate had Serena, Blair, Jenny, and Vanessa (Jessica Szohr). Chuck had Blair and Georgina. (Trivia: in the book, the character of Chuck is bisexual and has a boyfriend named Greg '' how hot is that?)
A recent cursory reading of the comments from Gossip Girl fans made me realize that the Chuck and Blair tandem is a pretty huge hit. It is understandable, the chemistry between these two is hotter as heck. Both are shrewd and cunning and borderline evil. On the other hand, from time to time, we see glimpses of goodness from these two demonized characters. In fact, the fans of this pairing have even lashed out at the photo of Nate kissing Blair which reportedly will occur in on an upcoming episode.
In the same manner, there are also fan sites wholly dedicated to Serena and Nate. I have to admit, I was initially quite fond of Nate and Serena perhaps because they looked like there were on the same page as far as their lives are concerned. Their relationship may be too tame for the wicked fans of Gossip Girl, and I understand how couples who have security and mutually support each other can appear boring to outsiders. This is actually the reason why I like Vanessa and Nate - because they are boring.
And what about Blair and Nate? This pairing is a fine example of the dominant girlfriend with the doormat boyfriend. Blair's personality is too strong for Nate. It takes someone as domineering and perhaps overbearing as Chuck to tame Blair. And we all know Blair needs all the taming in the world. Given all of these, I like the direction Gossip Girl is taking. If only they can stay faithful to the book and make Chuck bisexual. That'd be something to see.