Nana 2, the sequel to the first film, was announced right after the first debuted. However, on August 4, 2006, Toho stated that shooting would begin mid-September and that the film was to be released on December 9, 2006. Aoi Miyazaki and Ryuhei Matsuda would not be reprising their respective roles as Nana Komatsu and Ren Honjo; as such, their roles were assigned to Yui Ichikawa and Nobuo Kyou, respectively .
Two new singles were released under Nana starring Mika Nakashima and Reira starring Yuna Ito.
However, the sequel was a let-down for fans and company, it only peaked #4 at the Japanese Movie Rankings, and had much more bad press than any good.
The film had its international premiere in New York City on December 15, 2006. It opened for a single showing at the IFC in SoHo. Both Mika Nakashima and Yui Ichikawa were present.