The episode begins with Dennis Ryland giving a speech to a Congressional Hearing regarding the 4400, Ryland states to the panel of congressmen about how the promicin-inhibitor program was an international effort with a goal to stop the domination of the world by a small fraction of the population, the 4400.
Three weeks earlier Richard and Shawn walk down the corridors of the 4400 Center in a rush as Shawn has something important to show Richard, in regard to Isabelle. Arriving at their destination Richard is bemused to discover a young lady claiming to be his daughter, Isabelle. Richard returns to his apartment in search of Lily and Isabelle, looking around he discovers Lily has collapsed in their bedroom, when he goes to her aid to help her up he finds an aged woman, who claims to be Lily. As the aged Lily gets up she realizes her hands have succumbed to wrinkles and screams when she views her self in a mirror, Lily has aged exponentially.
Richard and Lily visit Dr. Kevin Burkhoff in regard to Lilyâs rapid aging, Burkhoff states that while her blood pressure is elevated her heart, lungs and reflexes are within the normal range. Burkhoff speculates that the rapid aging is due to Lily coming off the promicin-inhibitor.
The episode returns back to the present day with Ryland still giving his speech to panel of congressmen. Ryland âowns upâ and reveals the inhibitor program was all his idea, and states he was proud to lead it. After taking a short recess the panel and guests return to their seats, not long after however a loud noise emanates around the room. An advisor to Ryland begins to get agitated because of the noise which he can hear, rummaging through his briefcase he removes a letter opener and in a raged state stabs Ryland multiple times.
At his house, Tom and Alana talk about Ryland, with Tom suggesting that maybe he should contact Rylandâs wife to see if he can help her in any way, although Tom dismisses the idea stating that Ryland did nothing nor tell Tom when Kyle was stalking Jordan Collier. Alana suggests that she needs to get Tom away from there, away from his problems. Alana tells Tom that since coming of the promicin-inhibitor she believes she can control her ability. Tom and Alana could potentially take a long holiday in the space of a few moments.
NTAC receives a message from the Nova Group, the âdefensive wing of the 4400â, in their message they state that a second demonstration of their powers has been planned for October 19. Nina reintroduces Tom and Diana to Gary Navaro, Nina tells Tom and Diana how Garyâs telepathic powers have been very useful to the National Security Agency.
While Lily and Isabelle study several medical documents in Kevinâs office, they discover that there is a one-to-one correlation in such that every time one of Lilyâs neurons âturns offâ one of Isabelleâs âturns onâ.
At Dianaâs apartment her, Maia and Marco play a board game, when Maia asks if she can excuse her self from the game, leaving to go to her room Maia hints at the future to Marco. He tells Diana that maybe Maia was better off on the promicin-inhibitor due to being overwhelmed with knowing what will happen. Diana visits Kevin Burkhoff regarding Maia during the night; on entering his apartment Diana sees a vial of promicin on Kevinâs desk.
Tom and Diana receive a lead on Jeffrey Houser, a member of the Nova Group which Gary Navarro put Tom and Diana on to, they head to a morgue and discover that he had been dead for two weeks, much too long to be the person they are looking for. They realize Gary had been deceiving them.
The episode ends with Richard and Lily resting on a sofa while Isabelle heads to the top of the 4400 Center and jumps from the top of the building while Gary Navarro attends Dennis Rylandâs bedside, Gary states to Ryland âYouâre awake. Good. Itâs important you know itâs me, Iâm the guy who killed you.â Navaro then injects Ryland with an unknown substance which causes Ryland to go into a seizure.