Grey's Anatomy: Will Another Woman Come Between Alex and Izzie?

After taking a five-episode hiatus to shoot a film and spend time with her new daughter, Katherine Heigl will return to Grey's Anatomy for the Jan. 21 episode. Izzie's absence has certainly affected her hubby, Alex (Justin Chambers), who may not be able to forgive her for running out on their marriage. We caught up with Chambers on the set of Grey's, where he spilled that the pair's marital problems may send Alex running into another woman's arms.

When Izzie returns, Chambers says that she and Alex will have some work to do. "Alex is just fed up. He's not built for all of this. He really meant what he said when he committed to her at their wedding and now he just feels that it's all rushed too fast and he hasn't really necessarily thought things through. He has so much emotional baggage anyway."

"Did he really do the right thing?" Chambers ponders. "Maybe he didn't. Does she really love him or does she love the idea of them? She's got so much to work out on her own, that maybe they're not supposed to be together for a while, maybe never."

Alex seeks solace at Joe's bar, where his inebriation, as it often does on this show, sends him straight into a one-night stand. Who, you ask? We're sworn to secrecy, but Chambers hints that fans will be supremely shocked. "I was totally thrown off by it. I think it's great though. It just adds a little spice to the show. The writers are really good at turning corners and taking your head for a little spin. It surprised me as much as it will the audience."

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