Two Bristol-based young men, George (a werewolf) and Mitchell (a vampire), have formed a friendship and desire to live in as normal and human a way as possible. They move into a houseshare together only to discover that their new home is haunted by Annie, the ghost of a previous occupant. As the three endeavour to deal with each other and develop their friendships, George must deal with the unexpected return of the girlfriend whom he abandoned once he became a werewolf (and who does not know the truth of his condition), while Mitchell must deal with the imperial ambitions of the Bristol vampire clan and his recent creation of a new vampire, Lauren.