10 years after an unnatural phenomenon wiped out Tokyo, evacuee Igarashi Ganta lives an ordinary life going to middle school and hanging out with his friends. But the tranquil days come to an abrupt halt when a mysterious "Red Man" appears and massacres Ganta's classmates. Falsely accused of the murders, Ganta is sentenced to death and locked up in the country's only privately owned prison, "Deadman Wonderland." Yet in the midst of his despair, Ganta's new destiny begins to unfold!