“The Mystery Cruise” centers on best friends and impending partners, Alvirah Meehan (O’Grady), a lottery winner turned amateur sleuth and Regan Reilly (Harrison), a private investigator. After the two heroines rescue the diamond-collared pooch of a wealthy socialite (played by Carol Higgins Clark), they set off with their spouses to join Regan’s mom, Nora Reilly (Colleen Winton, “The 4400”), a world famous mystery writer, on a luxurious three day cruise around the San Juan Island off the coast of Washington, the setting for a mystery game created to promote the release of Nora’s latest book. As the boat calmly sets sail, everyone is enjoying getting into character, especially Alvirah, who may or may not be the “murderess” in the mystery game. But troubled waters lie ahead when Alvirah gets a hunch that a real killer may be on board and together with Regan the pair teams up to take the killer down. Back on the mainland, Alvirah and Regan hang out their shingle in their fabulous Manhattan office to continue their sleuthing and crime fighting ways!