Shemp is suffering from an enlarged vein in his leg, and fears that it will lead to amputation. His doctor (Vernon Dent), however, advises that a few weeks in the Old West will cure him. Upon arrival in a somewhat lawless town, the boys befriend the ruthless Doc Barker (Norman Willes). Barker listens to Shemp's story about his bad leg, mistaking "the biggest vein you ever saw" for a gold-bearing vein worth millions. The Stooges take a liking to Barker, but are later informed by the beautiful Nell (Christine McIntyre) that he is an outlaw who is holding her two sisters (Norma Randall and Ruth White) hostage in the basement of the saloon.