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This documentary series follows the unpredictable twists of missing person cases, tracking investigations aimed at solving how and why people simply vanish. While some of the resolutions are heartwarming and others tragic, many cases remain open to this day and continue to be a source of unbearable frustration for family members and friends.

Female murderers are often times more horrifying and intriguing than their male counterparts. Their worlds are often defined by obsession, greed, and revenge. Deadly Women fuses bone-chilling story-telling, sumptuous period drama and forensic fact in a bid to explore history's most alluring female killers. Each episode profiles four famous cases from the past; killers and their victims are brought to life by elaborate dramatized reconstructions. The program will span four centuries and seven countries to explore the makings of these deadly women. Candice DeLong, a former FBI agent and profiler, and Dr. Janis Amatuzio, a forensic pathologist will also join the program to give a deeper insight into the crimes and the women who commit them.