In 2016, a catastrophe occurs after a nuclear meltdown from the nearby Odaiba nuclear power plant contaminates Tokyo, forcing the government to order its citizens to evacuate. 20 years later, Tokyo has become a ghost town due to the high levels of radiation which the government has banned entry for anyone. When a distress signal is received from Tokyo, the Japan Ground Self-Defense Force dispatches 3 teenage girls from the Dispatch 3rd Special Force Coppelion, who comprise the "Healthcare Team". Due to genetic engineering, the Coppelions are immune to radiation while also possessing special skills. Thus the Coppelions journey to the ruined capital to find survivors.