On suspension for interfering in an investigation, and on the run for surreptitiously freeing a murderer to make amends, William Murdoch has left Toronto, and police work, for the Yukon in pursuit of solace and fortune and meets a man named Jack London. Back in the city, newly promoted Chief Constable Giles makes it clear to Inspector Thomas Brackenreid that he'll be keeping a very close eye on police matters. Meanwhile, Murdoch's beloved former associate, Dr. Julia Ogden, is now working alongside Acting Detective George Crabtree and Dr. Emily Grace, a feisty young protégé.