Big show with big names and quality writing... my only problem with it is that I found most of the characters unlikable which made for a difficult watch. I believe it was more so the actors' own spin on their characters that I disliked rather than the way the characters were written. If an all new cast were put into those roles I'm sure the new actors would have a different take, from facial expressions to the tone of the delivery of lines which may have resulted in me loving the show. But we'll never know.
I also found aspects of the plot to be unbelievable... I shouldn't have to suspend my disbelief when watching a show about a woman with cancer but so many things were just too over the top to be considered remotely possible for someone in her situation.