An accidental overdose of gamma radiation creates a mutation in David Banner's DNA, and, whenever he becomes angry, it causes him to metamorphose into a seven-foot-tall, 330-pound, green hulking creature. Tabloid newspaper reporter, Jack McGee begins investigating claims of a giant creature; his investigation leads to the laboratory that Banner was using. An explosion in the lab kills Banner's associate and friend Dr. Elaina Marks (Susan Sullivan); McGee, who dubs the creature "the Hulk", believes the Hulk killed David too. Unable to explain the truth, nor control his transformations, David leaves to try and find a cure for himself.