At the center of the series is U.S. Senator William Powers, a parody of the political establishment in Washington, D.C. Margaret, the senator's status-hungry wife, treats Charlotte, their maid, with comedic disdain. Caitlyn, the senator's daughter, has an eating disorder and is married to Representative Theodore Van Horne, who is suicidal; their son, Pierce, is mature beyond his years from having to care for his unbalanced parents. Sophie Lipkin, the senator's illegitimate daughter, is a loud, crass New Jerseyan who surprises the family when she moves to Washington and begins to bond with her father. The senator's staff includes an intelligent and beautiful aide, Jordan Miller — who is also Powers' mistress — and the feckless aide Bradley Grist.