How well do you know your friends? Would you bet your life on it? After spending every minute of the last two years living, working, and partying together, grad-school students Jay Burchell, Tyler Fog and Will Traveler depart on a cross-country road trip. But when an innocent prank at one of New York's oldest art museums coincides with the bombing of the iconic building, Jay and Tyler are blamed for the terrorist attack and realize that their "friend" Will may have been the one who framed them. Unable to find Will or any evidence that the Will Traveler they knew even existed, Jay and Tyler are forced to flee the city and go on the run.