After fighting what he believes to be an attempt to poison all black people, Black Dynamite comes down with the flu on the weekend of the annual Player's Ball, a party for pimps which this year is taking the form of a costume party on a cross-country train. However, Leroy Van Nuys (Snoop Dogg) hijacks the train in his attempt to take revenge on pimp-kind. With the help of the spirit of Sun Tzu, Dynamite must fight the flu and a horde of Isaac Washington robots to save his friends and pimps from all over the world.