Callie and her baby, Sofia, are recovering following the accident, but Callie has yet to actually see her daughter. Meanwhile, Alex gets an idea that he thinks will make him chief resident as he treats a cranky terminal-cancer patient (Doris Roberts); a patient's sudden death makes Derek more cautious in the clinical trial, but the same can't be said for Meredith; and Teddy is pleasantly surprised by the return of Andrew Perkins (James Tupper).