A troubled patient pays a return visit to Holby, but then goes missing from the ward. Essie resolves to find her wayward charge, but the search places her own life in jeopardy, and when Sacha realises she is missing from a family night out, a tragedy begins to unfold before his very eyes. Meanwhile, Serena struggles to manage the new trauma unit in light of Bernie's absence, and new doctor Jasmine Burrows makes a very good impression on Ollie as she bursts onto Darwin for her first shift.