Oprah and her platonic friend Gale discuss their latest adventures. Parents of celebrities encourage people to vote against gay adoptions. An overweight man joins a Chicago-style pilates class. A woman brings her date home to meet her two gay dads who happen to have enormous genitalia. Jeff Foxworthy hosts "Are You Smarter Than a Tranny Hooker?" Appearances by Rosie O'Donnell & Chastity Bono. Guest stars Kate Clinton.