Sixtus IV is dead. Lorenzo and Clarice go to Rome to try to influence the election of the new Pope, but they must confront the plots of Riario which aims to have his cousin Raffaele elected, thanks to plots inside the Curia. The Medici will find an unexpected ally in Caterina Sforza, wife of Riario, but the final victory will be achieved not without sacrifices. The new Pope Cybo, elected thanks to the money and the influence of the Medici, in fact, proves difficult to control and the part played by Lorenzo in his election provokes the anger of Savonarola, who defends the idea of ​​a Church guided by God and not from politics.