Savonarola, who had collected Tommaso's confession, denounced his killing and openly accused Lorenzo, who however continues to deny it. Clarice, who has discovered she is pregnant and hopes for a new beginning for her and her husband, begins to suspect the truth. With his health worsening, Lorenzo promises his daughter Magdalene's hand to the Pope's son, to carry out his strategy of control over the Holy See. This involves a definitive break with Clarice, whose sudden death casts Lorenzo into despair. The people are increasingly conditioned by the sermons of Savonarola, who risk bringing the Medici rule over Florence to the end.